Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
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چکیده
منابع مشابه
α‐synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease
OBJECTIVE Progressive accumulation of α-synuclein (α-syn) has been associated with Parkinson's disease (PD) and Dementia with Lewy body (DLB). The mechanisms through which α-syn leads to neurodegeneration are not completely clear; however, the formation of various oligomeric species have been proposed to play a role. Antibody therapy has shown effectiveness at reducing α-syn accumulation in the...
متن کاملNetwork dysfunction in α‐synuclein transgenic mice and human Lewy body dementia
OBJECTIVE Dementia with Lewy bodies (DLB) is associated with the accumulation of wild-type human α-synuclein (SYN) in neurons and with prominent slowing of brain oscillations on electroencephalography (EEG). However, it remains uncertain whether the EEG abnormalities are actually caused by SYN. METHODS To determine whether SYN can cause neural network abnormalities, we performed EEG recording...
متن کاملNeuroinflammation in Lewy body dementia.
Neuroinflammation is increasingly recognized as a key factor in the pathogenesis of neurodegenerative conditions. However, it remains unclear whether it has a protective or damaging role. Studies of Alzheimer's disease and Parkinson's disease have provided much of the evidence for inflammatory pathology in neurodegeneration. Here we review the evidence for inflammation in dementia with Lewy bod...
متن کاملSynphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease.
α-Synuclein is a major component of Lewy bodies in Parkinson disease (PD) and dementia with Lewy bodies (DLB). We recently showed that abnormal α-synuclein with resistance to proteinase K (PK) is deposited at presynapses of distinct brain anatomic regions from the early stages of PD and DLB. NUB1, a synphilin-1-binding protein, also accumulates in Lewy bodies, but it is not known whether abnorm...
متن کاملDeubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.
In Parkinson's disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson's pathogenesis. By comparative analysis in human postmortem brains, we found that ubiquitin immunoreactivity in Lew...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2020
ISSN: 1742-2094
DOI: 10.1186/s12974-020-01888-0